In a brief genetic report, an association between ApaI genotype and insulin secretion was reported in a study of 164 healthy Bangladeshi Asians at risk for type 2 diabetes; aa genotype was associated with a decrease insulin secretion compared to AA and Aa genotypes (68.5 vs 92.7 vs 146.8, p value=0.001) [185]. Here, INS is linked to type 2 diabetes mellitus.