In summary, although PXR is not currently considered as a gene involved in blood pressure or renal function, its role in controlling the expression of genes such as ABCB1 and CYP3A5, its involvement in steroid hormone metabolism, its actions on lipid and energy metabolism and inflammation as well as its interaction with VDR, all point toward PXR as being a putative important player in kidney diseases. The gene discussed is CYP3A5; the disease is kidney disorder.