For positive diagnosis of primary aldosteronism must be met biochemical criteria (the relationship between serum aldosterone and plasma renin or plasma renin activity is the strongest evidence) and imagistic evidence (CT or MRI abdomen); in addition, other investigations (adrenal veins catheterization for determination of aldosterone level, adrenal postural test, NP59 scintigraphy with cholesterol) helps locate and determine the type of aldosteronism. Here, REN is linked to primary aldosteronism.