In the present study, we found that the anti-CA III antibody titers in patients with RA, SLE, and T1DN were significantly higher than that in control group, respectively, while at least one of the antioxidant enzyme activity levels of MDA level in the serum of RA, SLE, T1D, T1DN, and T2DN patients was significantly lower than that in control group. The gene discussed is CA3; the disease is systemic lupus erythematosus.