IL1B and autoimmune disease: In the present study, we investigated the association of the rs2424913 single-nucleotide polymorphism (SNP) (C46359T) located into DNA methyltransferase 3B (DNMT3B) gene promoter and a VNTR polymorphism of IL-1 receptor antagonist (IL-1 Ra) intron-2 with an increased risk of ITP in children, in an attempt to elucidate the role of genetic and epigenetic mechanisms in the pathogenesis of such an autoimmune disease.