HP and ulcer disease: Besides in 6 age-matched controlled studies, ulcer was reported to be more common in Hp-positive than Hp-negative patients (OR, 4.03), irrespective of NSAID use, and in NSAID users than nonusers (OR, 3.10), irrespective of Hp status while the risk of ulcer was reported to be 17.54-fold higher in Hp-positive NSAID users than Hp-negative nonusers [12].