Nonetheless, based on the published reports stating the use of NSAIDs to be the major cause of and an independent factor associated with Hp-negative ulcer disease [1, 9], a careful history and examination of recent prescription records seems necessary to be certain that the patient is not taking unrecognized NSAIDs as well as over-the-counter medications including herbal medications, some of which contain salicylates [18]. Here, HP is linked to ulcer disease.