HP and peptic ulcer disease: Alike to our findings, in a systematic review [12] concerning effects of Hp and NSAIDs on PUD, in 21 studies involving 10,146 patients, uncomplicated peptic ulcer was reported to be more common in Hp-positive than Hp-negative patients (pooled odds ratio [OR], 2.17) or in Hp-positive than Hp-negative NSAID users (OR, 1.81).