The present study investigates the relationship between diabetes metabolic control represented by actual levels of HbA1c, early glycation products—(fructosamine (FAM)), serum-advanced glycation end products (s-AGEs), lipid peroxidation products (LPOs), advanced oxidation protein products (AOPPs), and circulating TGF-β in patients with DM1. This evidence concerns the gene TGFB1 and diabetes mellitus.