Several mechanisms are proposed to contribute in PPARγ antagonism to NF-κB. First, PPARγ, as already mentioned in the previous section, induces PTEN in pancreatic cancer cells which dephosphorylates and inhibits kinase PI3K blocking the signal from activated K-ras to NF-κB [62]. The gene discussed is KRAS; the disease is familial pancreatic carcinoma.