IGHE and Eczematoid dermatitis: In the recent study by Yesilova et al. (2012), children aged 1–3 years with a history of eczema were treated with a combination of B. bifidum, L. acidophilus, L. casei, and L. salivarius for 8 weeks and found reductions in SCORAD as well as serum cytokines IL-5, IL-6, IFN-γ, and total serum IgE levels, but not IL-2, IL-4, IL-10, or TNF-α compared to the placebo group.