In a mouse model of atopic dermatitis induced by house dust mite and dinitrochlorobenzene, treatment with a probiotic mixture containing L. acidophilus, L. casei, L, reuteri, B. bifidum, and Streptococcus thermophilus inhibited clinical progression as well as attenuating total and allergen-specific IgE levels, IL-4, IL-5, IL-10, and IL-13 levels associated with increased CD4+FoxP3+ Tregs in the ear (Klewicka et al., 2011). Here, IGHE is linked to atopic eczema.