IGHE and Eczematoid dermatitis: However, the use of a combined probiotic and prebiotic formulation (synbiotic) containing B. breve M-16V and a mixture of galacto- and fructo-oligosaccharides (GOS/FOS) were unable to improve eczema severity compared to placebo although an improved SCORAD was observed for infants with IgE-associated eczema (van der Aa et al., 2010).