For the combined prenatal/postnatal probiotic studies, there was a significant reduction in the cumulative incidence of eczema and/or IgE-associated eczema in six of the nine published RCTs (Kalliomaki et al., 2001b; Kukkonen et al., 2007; Wickens et al., 2008; Niers et al., 2009; Dotterud et al., 2010; Kim et al., 2010) by age 2 years. Here, IGHE is linked to Eczematoid dermatitis.