The expression of HSP90 was also higher in RAEB-II versus RAEB-I (p < 0.05) and there was a trend for higher levels in refractory cytopenia with multilineage dysplasia (RCMD) versus RA with or without ringed sideroblasts (p=0.06). This evidence concerns the gene HSP90AA1 and myelodysplastic syndrome with multilineage dysplasia.