In MDS/CMML MNC, HSP90 and other proteins levels were significantly higher in high-risk cases according to WHO classification (p<10−4, Figure 1, mean MFIR ± SD in refractory anaemia with excess of blasts RAEB (n=93) versus refractory anaemia RA (n=61) and CMML (n=23), respectively: 37 ± 21 versus 7 ± 4 and 22 ± 21 for HSP90, 26 ± 17 versus 6± 5 and 16 ± 16 for AKT, 33 ± 18 versus 5 ± 6 and 19 ± 23 for FAK, 31 ± 18 versus 3 ± 5 and 15 ± 16 for pFAK). The gene discussed is HSP90AB1; the disease is myelodysplastic syndrome.