In addition to TNF alpha, other important cytokines such as truncated tissue factor (tTF), interferon gamma (IFN gamma) and interleukin-12(IL-12) which have great potential as anti-cancer agents, have been fused with NGR/RGD peptides or other peptides targeting tumor blood vessels to enhance their anti-cancer activity [51-55]. This evidence concerns the gene TNF and neoplasm.