Five individual GNS signature genes were significantly associated with survival of glioblastoma patients in both of the two largest data sets: PLS3, HOXD10, TUSC3, PDE1C and the well-studied tumor suppressor PTEN. PLS3 (T-plastin) regulates actin organization and its overexpression in the CV-1 cell line resulted in partial loss of adherence [70]. The gene discussed is PDE1C; the disease is glioblastoma.