In this study, log(TG)/HDL-C was associated with lesser residual insulin secretion, as well as with more severe hyperbolic product (BxS) loss over time, and heralded poorer glycemic control and earlier or more intensive need for stepping-up glucose-lowering therapies, as we previously reported in T2DM males[7,22,23,29,41,42]. Here, INS is linked to type 2 diabetes mellitus.