As expected, luminal B showed more aggressive behaviors by traditional prognostic features, all basal-like tumros were ER negative, most HER2-enriched tumors showed IHC/FISH HER2 overe-expression, whereas only two-thirds of tumours with clinical ER-negativity/HER2 over-expression were predicted as HER2-enriched subtype according to the gene expression assays, and these findings were grossly in concordance with our knowledge about each breast cancer molecular subtype. This evidence concerns the gene ESR1 and neoplasm.