For 44 Taiwanese breast cancers with survival data, we did find a trend toward good prognosis for luminal A subtype and worse prognosis for luminal B and HER2-enriched subtype, and a survival benefit of basal-like over HER2-enriched subtype was also observed, especially when subgroup analysis was performed according by IHC ER status. The gene discussed is ESR1; the disease is breast cancer.