RB1 and breast carcinoma: We first downloaded the 15 breast cancer related genes from the Cancer Gene Census [23]: AKT1, BAP1, BRCA2, CCND1, CDH1, EP300, ERBB2, ETV6, GATA3, MAP2K4, NTRK3, PBRM1, PIK3CA, RB1, and TP53.