In lesions with BRAF or KRAS mutation c-MYC and SIRT1 expression was low to moderate in hyperplastic polyps and sessile serrated adenomas (Figure 2a, b), moderate to high in lesions with low grade intraepithelial neoplasia (Figure 2c, d), and high in lesions with high grade intraepithelial neoplasia (Figure 2e, f) and invasive serrated carcinomas (Figure 2g, h) (summarized in Figure 3, supplementary tables 1 and 2). This evidence concerns the gene SIRT1 and intraepithelial neoplasia.