BRAF and intraepithelial neoplasia: BRAF mutation was found in 73 cases comprising 20 hyperplastic polyps, 24 sessile serrated adenomas without intraepithelial neoplasia, 2 sessile serrated adenomas with low grade intraepithelial neoplasia, 8 sessile serrated adenomas with high grade intraepithelial neoplasia, 10 traditional serrated adenomas with low grade intraepithelial neoplasia, 1 traditional serrated adenoma with high grade intraepithelial neoplasia and 8 invasive serrated adenocarcinomas (table 1).