To date, the most effective treatments for diabetic nephropathy (DN) are the antihypertensive drugs, particularly those that target the renin–angiotensin system (RAS) such as ACE inhibitors, angiotensin-1 receptor antagonists, or their combination.25,30,31 Although these treatments may retard the progressive decline in renal function in diabetes, clinical trials suggest that there is no effective treatment for DN.8 The gene discussed is ACE; the disease is liver dysplastic nodule.