For example, morroniside isolated from Corni fructus has shown reno-protection in experimental diabetes through a reduction in the production of AGEs.64 Additionally, some plants have been shown to cause an improvement in renal function in experimental diabetes mellitus through inhibition of ET-1 and TGF-β1 and the endothelin-1 receptor A (ETRA).65 This evidence concerns the gene EDNRA and diabetes mellitus.