Data from our study including: 1) the bioenergetics analysis in melanoma cells derived directly from patients; 2) the immunohistochemical analysis of ATP5A1, a key regulatory component of the mitochondrial respiratory chain; and 3) high expression of LDHB, a key enzyme that converts lactate to pyruvate, all support the importance of OXPHOS in melanoma. The gene discussed is LDHB; the disease is melanoma.