SLC16A1 and cancer: Given that lactate produced by glycolytic cells can be taken up by OXPHOS-dependent cancer cells via MCTs under an ATP-independent passive diffusion that follows substrate gradients and H+ transport [10] it is a possibility that disrupting MCT function might be catastrophic for cells that are dependent on glycolysis, for the reason that the cells may not be able to release lactic acid, resulting in lowering the pH and death [27].