Four of these SNPs showed associations close to genome-wide significance in the discovery cohort: rs225132 in the ERRF11 gene and rs17696736 in the NAA25 (C12orf30) gene with all ischaemic stroke (p=6·3×10−8 and 5·9×10−8, respectively), rs7937106 in ALKBH8 with large-vessel disease (p=5·9×10−8), and rs13407662 on chromosome 2p16.2 (p=5·2×10−8) in an intergenic region with small-vessel disease. This evidence concerns the gene ALKBH8 and ischemic stroke.