We identified associations at four loci that were near genome-wide significance in the discovery cohort and had not been associated with stroke in previous studies: SNPs in the ERRF11 and NAA25 (C12orf30) genes with all ischaemic stroke, a SNP in ALKBH8 with large-vessel stroke, and rs13407662 on chromosome 2p16.2 in an intergenic region with small-vessel disease. The gene discussed is ALKBH8; the disease is ischemic stroke.