CRP and rheumatoid arthritis: Indeed, a recent study by Rhodes et al. (2010) observed that haplotypes of common SNPs within the CRP locus were correlated with CRP levels in two cohorts of patients with RA [16], although it should be noted that both cohorts had modestly active disease as determined by their median CRP levels (11 mg/L and 5 mg/L in the discovery and replication cohorts, respectively) [16].