TNF and rheumatoid arthritis: Specifically, we aimed to investigate haplotypes at the CRP gene defined by three variants (rs1205, rs1800947 & rs3091244), which have previously been associated with levels of CRP production, to determine their association with baseline CRP levels, baseline DAS28-CRP and change in DAS28-CRP in patients with RA before and after 6 months therapy with an anti-TNF drug.