By the immunohistochemistry, the diffusely and strongly positive signals for Ezrin protein was detected in the cytoplasm of gastric cancer cells; however, negative or scattered positive cells (mainly basal reserve cells) was observed in the cytoplasm of normal gastric epithelia, indicating that the subcellular distribution of Ezrin was predominantly cytoplasmic distribution in non-migrating cancer or normal cells, but mainly membranous distribution in the migrating cells in vitro. Here, EZR is linked to cancer.