For the TNM clinical stages, Ezrin positive rate was only 35.8% (49/137) in early clinical stage (35.9% in Stage 0, 25.5% in stage IA and 45.1% in stage IB) of gastric cancer, however significantly higher in late stage cases (85.0%, 119/140) (78.7% in Stage II, 91.5% in stage III, and 100% in stage IV), and the difference was statistically significant (P<0.05). Here, EZR is linked to gastric cancer.