Pathways over represented among genes down-regulated in ERC-B were Hepatic fibrosis/hepatic stellate cell activation, TGF-B signaling, atherosclerosis signaling, mTor signaling, human embryonic stem cell pluripotency and hedgehog signaling and the cancer signaling pathways, ovarian cancer signaling, basal cell carcinoma and HER-2 signaling in breast cancer (Figure6). The gene discussed is TGFB1; the disease is cancer.