Among nonsmokers, 8 of 10 Asp/Asp (80%) carriers versus 5 of 16 Asp/Glu + Glu/Glu (31%) carriers with p53 mutation had squamous cell carcinoma; however, 12 of 30 Asp/Asp carriers (40%) versus 11 of 48 Asp/Glu + Glu/Glu (23%) with p53 mutation had adenocarcinoma. Here, TP53 is linked to squamous cell carcinoma.