However, a biological function of hOGG1 Ser326Cys polymorphism was not supported, as the hOGG1-Cys variant was not associated with p53 mutation in patients with lung cancer.30 This discrepancy may have been due to the predominant influence of APE1 on the DNA glycosylase activity of hOGG1. The gene discussed is TP53; the disease is lung cancer.