Substantial evidence indicates that hOGG1 Ser326Cys is associated with an increased risk of lung cancer.16–20 An early in vitro study provided cellular evidence that, as compared with the hOGG1 Ser/Ser genotype, the hOGG1-Cys variant results in less repair of 8-hydroxyguanine in damaged DNA.29 A more recent study confirmed this finding and also noted that the hOGG1-Cys variant resulted in less DNA glycosylase activity as compared with the hOGG1-Ser/Ser genotype. Here, OGG1 is linked to lung cancer.