Furthermore, MyD88 and TRIF inhibitors inhibited LPS-induced production of IL-12p35 in joint cells from WT mice with arthritis as compared with cells treated with a control peptide, indicating that LPS-mediated IL-12p35 production during antibody-induced arthritis depends on MyD88 and TRIF (Figure 2C). The gene discussed is MYD88; the disease is Arthritis.