KRAS and sarcoma: Thus, given the cellular similarities between undifferentiated pleomorphic sarcomas and rhabdomyosarcomas [52], it is imperative to further investigate sarcomagenesis in the Kras-LSLG12D;p53Fl2Δ10/Fl2Δ10 mouse models using multiple myospecific Cre-expressing transgenic mice in order to precisely ascertain how these pathways synergies in specific tissues.