Since there are likely to be gaps in public databases of processes relevant to peroxisome biology and X-ALD pathogenesis, we conducted a manual inspection of gene annotations provided by the DAVID bioinformatics resource and found multiple DEGs involved in immune related processes, but only two (CBLB and RAB27A) of these genes were not associated with the site of biopsy. This evidence concerns the gene RAB27A and X-linked adrenoleukodystrophy.