ANGPT1 and serum lipopolysaccharide activity: Notably, MAT.Ang-1 did not change the arteriolar diameter during sepsis and normal conditions, suggesting that: the effects of MAT.Ang-1 on microvascular permeability and blood flow in pathological (endotoxemia) and physiological conditions are not dependent on changes in microvascular resistance; and MAT.Ang-1-induced recovery of microcirculatory tissue perfusion during sepsis is due to preservation of endothelial barrier integrity.