Moreover, while previous studies have shown protective effects by repeated prophylactic or therapeutic injections of recombinant Ang-1 [45] or the Tie-2 agonist Vasculotide [46] in murine sepsis, the current study demonstrates that a single administration of the stable variant MAT.Ang-1 after the onset of sepsis improved endotoxemia-induced microvascular dysfunction. The gene discussed is ANGPT1; the disease is Sepsis.