For instance, despite a strong predictive association of Nuc-Stat5a in CSS analyses in Material VI, TTR in Material VI failed to reach statistical significance by univariate log-rank (P = 0.11) and multivariate Cox regression models (P = 0.087), whereas univariate Cox regression in Material VI indicated a twofold significant increased risk of breast cancer recurrence (P = 0.033). This evidence concerns the gene STAT5A and breast cancer.