In previous studies, the ancestral allele of the missense polymorphism rs1044498 (Q121K) has been associated with more vivid insulin receptor binding, stronger inhibition of insulin signalling, insulin resistance, an increased risk of T2D and an increased risk of myocardial infarction (OMIM ID: 608446) [9,44,45]. Here, INSR is linked to myocardial infarction.