Published data about AGT suggests that the ancestral allele of the probable pathogenic SNP rs699 (M268T), as well as the ancestral alleles of the missense SNP rs4762 (T207M) and the 5′UTR SNP rs5051, predispose to essential hypertension, increased plasma angiotensinogen and increased frequency of preeclampsia (OMIM ID: 189800) [18,41,42]. The gene discussed is AGT; the disease is hypertensive disorder.