The 2 most common heterozygote GBA mutations associated with PD (N370S and L444P)7 have been reported to undergo UPR/ERAD in cultured cells.24, 25, 34 However, 2 Gaucher mouse studies could not find evidence of UPR/ERAD in the brain.17, 35 UPR/ERAD markers were increased in both PD brains with GBA mutations and sporadic PD. The gene discussed is GBA1; the disease is Parkinson disease.