CD4 and experimental autoimmune encephalomyelitis: This reinforces the immunosuppressive capacity of α-MSH.1 Interestingly, IL-10 levels are subnormal in progressive MS.16 α-MSH and ACTH induce regulatory T cells (Tregs) that suppress disease in the experimental autoimmune encephalomyelitis (EAE) model of MS.17 In experimental autoimmune uveitis, α-MSH helps convert primed CD4+ T cells into CD4+, CD25+ Tregs that suppress disease; conversion is driven by MC5R binding.1 Perhaps of relevance, CD8+ Tregs function minimally during MS attacks.18