Clinical trials have demonstrated similar group efficacies for ACTH and IV steroids in MS relapses.37 A three-day course of IV treatment has advantages over a protracted course of IM injections in terms of patient comfort and medical resources,37 although these advantages might be offset should ACTH be shown to heighten motivation, arousal, attention, memory and learning in MS patients as it does in healthy individuals. Here, POMC is linked to myeloid sarcoma.