These results indicate that endogenous mesothelin not only enhanced the expression of the anti-apoptotic proteins Bcl-2 and Mcl-1, but also reduced the expression of the pro-apoptotic protein Bax[10].In the present study,we study whether mesothelin regulates proliferation and apoptosis in pancreatic cancer cells through p53-bcl-2/bax pathway. The gene discussed is TP53; the disease is familial pancreatic carcinoma.