TP53 and pancreatic neoplasm: Furthermore, mesothelin-induced pancreatic cancer cell proliferation also involves alteration of cyclin E via activation of signal transducer and activator of transcription protein-3[16], in this study,overexpressing mesothelin in MIA PaCa-2 cells with mt-p53 significantly increased cell proliferation and faster cell cycle progression compared with control cells, and silencing mesothelin in BxPC-3 cells with mt-p53 showed slower proliferation and slower entry into the S phase than control cells[16].