RB1 and cancer: The targetome also showed a significant relationship with IPA functional networks of cancer, cell growth, proliferation, development, and death, and cell cycle, and KeyMolnet pathways of transcriptional regulation by Rb/E2F, cAMP responsive element biding protein (CREB), glucocorticoid receptor (GR), vitamin D receptor (VDR), nuclear factor-kappaB (NF-κB), hypoxia inducible factor (HIF), p53, and AP-1.