Notably, two large studies (with sample sizes n = 843 and 768, [24,25], respectively) have shown that tumor immune infiltrate patterns and subsets in colorectal cancer are significant prognostic biomarkers, even after adjusting for stage, lymph node count, and well-established prognostic tumor molecular biomarkers including microsatellite instability (MSI), BRAF mutation, and LINE- hypomethylation. The gene discussed is BRAF; the disease is neoplasm.