ΔDNase regions that underwent a decrease in chromatin accessibility with AR activation did not exhibit an enrichment of the AR motif, but we uncovered a motif consistent with activator protein 2, which has been implicated in estrogen receptor binding and function [37], and its DNA motif is found in the promoter regions of several AR-regulated genes in prostate cancer [38]. The gene discussed is ESR1; the disease is prostate cancer.