Among the 564 unique genes (1,101 total probes) related to cell cycle pathways on the Illumina BeadChip, 42 genes including several key regulators such as APC, CDKN2A and 2B, and RASSF1 harboured greater than 20% average methylation change in at least 3 tumor types (30 hypermethylated and 12 hypomethylated genes as seen in Additional file2: Figure S7). The gene discussed is CDKN2A; the disease is neoplasm.