LBX1 and neoplasm: Among the ninety two hypermethylated concepts identified in the directional analysis (Figure1), over 50% of them are involved in early development and morphogenesis such as neurogenesis (FDR < 1×10-10 in 5 tumor types), homeobox (FDR < 1×10-10 in 5 tumor types), and embryonic development (FDR < 1×10-7 in 5 tumor types) (Additional file2: Figure S1A).