So far the focus on GR-mediated action of glucocorticoids in a neuronal context has remained largely in the dark and most of the knowledge on GR modes of action, GR responsive genes and pathways and crosstalk partners of GR has come from studies on peripheral tissues including the immune system, the respiratory tract, skeletal muscle and adipose tissue as well as various types of cancer cells [40-42]. Here, NR3C1 is linked to cancer.