NR3C1 and lung carcinoma: The onset of high-throughput sequencing combined with chromatin immunoprecipitation (ChIP-Seq) has made it possible to characterize genome-wide binding sites of TFs and today several studies have used this approach to identify global primary GR-targets in a variety of cell types, including human lung carcinoma cells (A549), mouse adipocytes (3T3-L1), premalignant breast epithelial cells (MCF10A-Myc), murine mammary epithelial cells (3134) and pituitary (AtT-20) cells [24-27].