For instance, CD44v6 interacts with c-Met, the receptor of hepatocyte growth factor (HGF), thereby increasing the survival and proliferative ability of tumor cells That is one of the reasons why the expression of the CD44 splice variant CD44v6 is correlated with the metastasis of colon cancer to the liver and a poor clinical prognosis[8]. This evidence concerns the gene HGF and neoplasm.