Extensive necrosis observed in the pulmonary granulomas in our study as well as a marked up regulation of several of these lipid homeostasis related genes, such as, ABHD2, ABHD8, ACSL1, ACSL5, CYP27A1, CYP2B18A, CYP26B1, CYP2F1, CYP2A13, CYP1A2, CYP11A1, CYP2D40, CYP2F1, FDPS, HADHA and LPL correspond well with the observations associated with human caseous granulomas[15]. The gene discussed is CYP26B1; the disease is Granuloma.