Secondary glioblastomas develop more frequently in younger patients and often contain TP 53 mutation (65%), whereas primary glioblastomas affect mostly elderly patients and generally are characterized by the loss of heterozygosity 10 q (LOH 10q) (70%), epidermal growth factor receptor amplification (36%), and TP 53 mutation at a frequency of lower than 30%[10]. The gene discussed is EGFR; the disease is glioblastoma.