Although the two analyzed NLRP3 SNPs were already successfully used to associate this gene to various diseases such as autoimmune (type 1 diabetes, celiac disease, SLE) [6] or infectious diseases (HIV-1) [10], it is possible that they could not be totally representative of the entire gene and deeper investigation will be needed to definitively exclude the association between NLRP3 and asbestos-induced mesothelioma. This evidence concerns the gene NLRP3 and infectious disease.