TWIST1 and cancer: Among the many known transcription factors regulating EMT, we focused on SNAI1 and TWIST1 because (i) both are considered as master regulators of EMT and are as such examples for direct (Snail) and indirect (Twist) suppressors of E-Cadherin (CDH1) [3], (ii) both are considered to be important for metastasis in several cancer types [1], [3], [6], and (iii) the aberrant expression of both is frequently reported in colorectal cancer (CRC) [7], [8], [9], [10], [11], [12], [13].