OGT and neoplasm: It is interesting to note that Akt is not modified by O-GlcNAc in the MDA-MB-231 or OVCAR-4 tumor cell lines and that the loss of OGT expression does not alter levels of phosphorylated Akt (at S473) in both the OVCAR-4 and MDA-MB-231 tumor cell lines (not shown), the latter of which is consistent with previous work [26].