It is of note that only one gene, VAV3, a guanine nucleotide exchange factor which has been shown to be an effector for multiple receptor tyrosine kinases [38], [39], overlapped between the present work and the work by O'Brien et al. [6], as a candidate biomarker of de novo sensitivity of breast tumor cell lines to GDC-0941. Here, NTRK1 is linked to breast neoplasm.