Finally, histological analysis of heart sections revealed that CVB3 infected mice treated with saline or Ad-LacZ developed severe myocarditis on day 7 with diffuse inflammation, whereas Ad-A20 treatment led to a significant remission of myocarditis showing few restricted mononuclear inflammation foci and tiny necrosis (P<0.05) (Figure 3D). The gene discussed is TNFAIP3; the disease is myocarditis.