The results showed that the mRNA expression levels of AHCY (0.0064±0.00067 vs 0.0074±0.00076 vs 0.0121±0.00137, P = 0.003), ACO2 (0.20±0.014 vs 0.20±0.034 vs 0.56±0.087, P<0.001), OXCT1 (0.0043±0.00037 vs 0.0036±0.00029 vs 0.0059±0.00054, P = 0.039) and CAP1 (0.094±0.0095 vs 0.059±0.0052 vs 0.135±0.0109, P = 0.004) were significantly reduced in both HD patients and preHD carriers when compared with the controls by ANCOVA with adjustment of age and gender (Table 2). This evidence concerns the gene OXCT1 and Huntington disease.