SIRT1 activity can be regulated by the endogenous activator AROS (active regulator of SIRT1) [23], inhibitors (deleted in breast cancer-1 (DBC1) and Tat) [24], [25], [26], NAD+ concentration [27], and by posttranslational modifications such as phosphorylation [28], [29], [30]. Here, SIRT1 is linked to cancer.