MMP2 and hepatocellular carcinoma: We found p38 MAPK inhibition by SB202190 could significantly attenuate the inhibitory action of genipin on in vitro migration and invasion of HepG2 and MHCC97L cells (Fig. 6A&6B).As well, the suppression of MMP-2/9 activities by genipin in HCC cells was attenuated by co-treatment with p38 MAPK inhibitor SB202190 (Fig. 6C).