TARDBP and amyotrophic lateral sclerosis: Our laboratory has previously generated a heterozygote knock-in VCPR155H/+ mouse model [34], with relatively mild progressive muscle weakness, microCT evidence of Paget-like lesions at the ends of long bones and progressive cytoplasmic accumulation of TDP-43, ubiquitin-positive inclusion bodies and increased LC3-II staining in the quadriceps, brain and spinal cord pathology of the motor neurons cells, suggestive of ALS.