Because perilipin has been shown to play pivotal roles in adipocyte lipid metabolism and has been shown to have an association with obesity in humans and experimental animal models [42]–[45], the present signal may reflect the effects of nearby genes, including PLIN1. However, the association of rs2028299 with BMI in the present study was modest, and a larger association study is required to clarify the association of this locus with BMI. This evidence concerns the gene PLIN1 and obesity due to melanocortin 4 receptor deficiency.