EGFR and neoplasm: Tumor tissue sections from the control group exhibited the highest grade of EGFR positive staining (3+) compared with high dose treatment groups (5 mg/kg/day group, 1+; 2.5 mg/kg/day group = 1+∼2+, p<0.05, Figure 5), but no significant difference was noted versus the 0.5 mg/kg/day group (2+∼3+, p>0.05).