There was a trend, although not statistically significant, that Mdm2+/−Arf+/−p53+/− mice developed more hemangiosarcomas and less soft tissue sarcomas, whereas Mdm2+/+Arf+/−p53+/− mice developed more soft tissue sarcomas and less hemangiosarcomas (Table 3). This evidence concerns the gene MDM2 and soft tissue sarcoma.